Structure-activity studies on amphetamine analogs using drug discrimination methodology.

@article{Glennon1984StructureactivitySO,
  title={Structure-activity studies on amphetamine analogs using drug discrimination methodology.},
  author={Richard A Glennon and Richard Young and A E Hauck and James E McKenney},
  journal={Pharmacology, biochemistry, and behavior},
  year={1984},
  volume={21 6},
  pages={895-901}
}
Animals (rats) trained to discriminate 1.0 mg/kg of S(+)-amphetamine sulfate from saline, using a standard operant training procedure, were administered doses of various amphetamine analogs in tests of stimulus generalization in order to study structure-activity relationships (SAR). The types of structural variation of the amphetamine molecule that were investigated included (a) benz-fusion of the aromatic nucleus, (b) alpha-demethylation of the alkyl side chain, (c) conversion of the benzylic… CONTINUE READING

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