Structure-activity studies of neurokinin A

@article{Rovero1989StructureactivitySO,
  title={Structure-activity studies of neurokinin A},
  author={Paolo Rovero and Vittorio Pestellini and N. -E. Rhaleb and St{\'e}phane B. Dion and Domenico Regoli},
  journal={Neuropeptides},
  year={1989},
  volume={13},
  pages={263-270}
}
A structure-activity study on neurokinin A and its C-terminal fragment NKA (4-10) has been performed in order to find selective agonists for the NK-2 receptor and identify chemical modifications suitable for protecting the peptides from degradation, while maintaining activity. Five series of compounds have been prepared and tested: 1. the complete series of the L-Ala monosubstituted analogues of NKA; 2. a series of NKA fragments from the C- or N-terminal; 3. the complete series of NKA (4-10… CONTINUE READING

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Human isolated small intestine: motor responses of the longitudinal muscle to field stimulation and exogenous neuropeptides

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  • 1989
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