Structure-activity studies of fluoroalkyl-substituted gamma-butyrolactone and gamma-thiobutyrolactone modulators of GABA(A) receptor function.

@article{Canney1998StructureactivitySO,
  title={Structure-activity studies of fluoroalkyl-substituted gamma-butyrolactone and gamma-thiobutyrolactone modulators of GABA(A) receptor function.},
  author={Daniel J. Canney and Hwang Fun Lu and Amy McKeon and Kyeng Won Yoon and Kuiying Xu and Katherine D. Holland and Steve Rothman and James A. Ferrendelli and Douglas F Covey},
  journal={Bioorganic & medicinal chemistry},
  year={1998},
  volume={6 1},
  pages={43-55}
}
Dihydro-2(3H)-furanones (gamma-butyrolactones) and dihydro-2(3H)-thiophenones (gamma-thiobutyrolactones) containing fluoroalkyl groups at positions C-3, C-4, and C-5 of the heterocyclic rings were prepared. The anticonvulsant/convulsant activities of the compounds were evaluated in mice. Brain concentrations of the compounds were determined and the effects… CONTINUE READING