Structure-activity studies of aspirin and related compounds on platelet aggregation, arachidonic acid metabolism in platelets and artery, and arterial prostacyclin activity.

@article{Killackey1982StructureactivitySO,
  title={Structure-activity studies of aspirin and related compounds on platelet aggregation, arachidonic acid metabolism in platelets and artery, and arterial prostacyclin activity.},
  author={John J. F. Killackey and Barbara A. Killackey and Richard B. Philp},
  journal={Prostaglandins, leukotrienes, and medicine},
  year={1982},
  volume={9 1},
  pages={9-23}
}
A series of benzoic acid derivatives was tested for specificity of action on human platelet function and platelet prostaglandin (PG) synthesis versus prostacyclin (PGI2) production by rat and rabbit aorta rings. None of the agents tested was more specific for one system than the other. ASA was more potent than 2-propionyloxybenzoic acid (2-PBA) in… CONTINUE READING