Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure.

Abstract

The Wnt signaling pathway plays a key role in regulation of organ development and tissue homeostasis. Dysregulated Wnt activity is one of the major underlying mechanisms responsible for many diseases including cancer. We previously reported the FDA-approved anthelmintic drug Niclosamide inhibits Wnt/β-catenin signaling and suppresses colon cancer cell… (More)
DOI: 10.1016/j.bmc.2015.07.001

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@article{Mook2015StructureactivitySO, title={Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure.}, author={Robert A. Mook and Jiangbo Wang and Xiu-rong Ren and Minyong Chen and Ivan Spasojevi{\'c} and Larry S Barak and H. Kim Lyerly and Wei Chen}, journal={Bioorganic & medicinal chemistry}, year={2015}, volume={23 17}, pages={5829-38} }