Structure-activity relationships study of 6-chloro-4-(2-chlorophenyl)-3-(2-hydroxyethyl) quinolin-2(1H)-one derivatives as novel non-nucleoside anti-hepatitis B virus agents.

Abstract

A series of novel 6-chloro-4-(2-chlorophenyl)-3-(2-hydroxyethyl) quinolin-2(1H)-one derivatives were synthesized and evaluated for anti-hepatitis B virus (anti-HBV) activities in vitro to explore their structure-activity relationships (SARs). Most of the synthesized compounds possessed potent anti-HBV activity, of which the promising compound 44 exhibited… (More)
DOI: 10.1016/j.ejmech.2010.11.019

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@article{Guo2011StructureactivityRS, title={Structure-activity relationships study of 6-chloro-4-(2-chlorophenyl)-3-(2-hydroxyethyl) quinolin-2(1H)-one derivatives as novel non-nucleoside anti-hepatitis B virus agents.}, author={Rui-Hua Guo and Quan Zhang and Yun-bao Ma and Jie Luo and Chang-An Geng and Lijun Wang and Xuemei Zhang and Jun Gang Zhou and Zhi-Yong Jiang and Jijun Chen}, journal={European journal of medicinal chemistry}, year={2011}, volume={46 1}, pages={307-19} }