Structure-activity relationships of untenone A and its derivatives for inhibition of DNA polymerases.

@article{Saito2004StructureactivityRO,
  title={Structure-activity relationships of untenone A and its derivatives for inhibition of DNA polymerases.},
  author={F. Saito and R. Takeuchi and T. Kamino and K. Kuramochi and F. Sugawara and K. Sakaguchi and Susumu Kobayashi},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2004},
  volume={14 8},
  pages={
          1975-7
        }
}
We found that untenone A and mannzamenone A inhibit mammalian DNA polymerases alpha and beta, and human terminal deoxynucleotidyl transferase (TdT). The syntheses of both compounds and the structure-activity relationships of untenone A derivatives are described. 
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Topics from this paper

Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase.
Synthetic and Structure-Activity Relationship Studies on Bioactive Natural Products
  • K. Kuramochi
  • Chemistry, Medicine
  • Bioscience, biotechnology, and biochemistry
  • 2013
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