Structure-activity relationships of thiazole and thiadiazole derivatives as potent and selective human adenosine A3 receptor antagonists.

@article{Jung2004StructureactivityRO,
  title={Structure-activity relationships of thiazole and thiadiazole derivatives as potent and selective human adenosine A3 receptor antagonists.},
  author={K E Jung and Soo-Kyung Kim and Z L Gao and Ariel S Gross and N. Melman and Kenneth A. Jacobson and Yong-Chul Kim},
  journal={Bioorganic & medicinal chemistry},
  year={2004},
  volume={12 3},
  pages={613-23}
}
4-(4-Methoxyphenyl)-2-aminothiazole and 3-(4-methoxyphenyl)-5-aminothiadiazole derivatives have been synthesized and evaluated as selective antagonists for human adenosine A3 receptors. A methoxy group in the 4-position of the phenyl ring and N-acetyl or propionyl substitutions of the aminothiazole and aminothiadiazole templates displayed great increases of… CONTINUE READING