Structure-activity relationships of the lissoclinamides: cytotoxic cyclic peptides from the ascidian Lissoclinum patella.

@article{Hawkins1990StructureactivityRO,
  title={Structure-activity relationships of the lissoclinamides: cytotoxic cyclic peptides from the ascidian Lissoclinum patella.},
  author={C. Hawkins and M. Lavin and K. Marshall and A. L. van den Brenk and D. Watters},
  journal={Journal of medicinal chemistry},
  year={1990},
  volume={33 6},
  pages={
          1634-8
        }
}
Two new lissoclinamides (lissoclinamides 7 and 8) have been isolated from the aplousobranch ascidian Lissoclinum patella. These lissoclinamides are cyclic heptapeptides with the same structural features as lissoclinamides 4 and 5 reported earlier, containing an oxazoline ring, one proline, one valine, two phenylalanine residues, and thiazole and/or thiazoline rings. All four peptides have the same sequence of amino acids around the ring and differ from one another only in their stereochemistry… Expand
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