Structure-activity relationships of the ATP cofactor in ligase-catalysed oligonucleotide polymerisations.


A T4 DNA ligase-catalysed oligonucleotide polymerisation process has been recently developed to enable the incorporation of multiple functional groups throughout a nucleic acid polymer. T4 DNA ligase requires ATP as a cofactor to catalyse phosphodiester bond formation during the polymerisation process. Herein, we describe the structure-activity relationship… (More)
DOI: 10.1039/c6ob02792j

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