Structure-activity relationships of some hederagenin diglycosides: haemolysis, cytotoxicity and apoptosis induction.

Abstract

Hederagenin saponins are largely represented in nature and possess many biological activities such as haemolytic, antiviral, fungicidal, molluscicidal or cytotoxic, partially due to their interaction with the cell membrane. The lysis of erythrocytes (haemolysis) is a simple test to evaluate this adsorption, and this activity has been linked to the structure… (More)

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