Structure-activity relationships of saponins enhancing the cytotoxicity of ribosome-inactivating proteins type I (RIP-I).

@article{Boettger2013StructureactivityRO,
  title={Structure-activity relationships of saponins enhancing the cytotoxicity of ribosome-inactivating proteins type I (RIP-I).},
  author={Stefan Boettger and Elena Westhof and Karsten Siems and Matthias Friedrich Melzig},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2013},
  volume={73},
  pages={144-50}
}
Saponins are amphiphilic secondary plant compounds able to interfere with surfaces and permeabilize membranes. In addition to antimicrobial and anti-inflammatory features, anti-neoplastic activities are described which base on various mechanisms. A very promising anti-cancer strategy is the synergistic enhancement of the cytotoxicity of ribosome-inactivating proteins type I (RIP-I) by suitable saponins. The cytotoxicity of the naturally low cytotoxic activity showing RIP-I can be augmented up… CONTINUE READING