Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists.

@article{Lan1999StructureactivityRO,
  title={Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists.},
  author={Ruoxi Lan and Qian Liu and Pusheng Fan and Shuqun Lin and Susanthi R. Fernando and D S McCallion and Roger G Pertwee and Alexandros Makriyannis},
  journal={Journal of medicinal chemistry},
  year={1999},
  volume={42 4},
  pages={769-76}
}
As a potent, specific antagonist for the brain cannabinoid receptor (CB1), the biarylpyrazole N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A; 1) was the lead compound for initiating studies designed to examine the structure-activity relationships of related compounds and to search for more… CONTINUE READING