Structure-activity relationships of protoberberines having antimicrobial activity.

@article{Iwasa1998StructureactivityRO,
  title={Structure-activity relationships of protoberberines having antimicrobial activity.},
  author={Kinuko Iwasa and Hiroaki Nanba and Dong Ung Lee and S. I. Kang},
  journal={Planta medica},
  year={1998},
  volume={64 8},
  pages={748-51}
}
13-Alkyl derivatives (2-6 and 8-12) of berberine (1) and palmatine (7) were subjected to in vitro antibacterial activity tests against Bacillus subtilis and Salmonella enteritidis. Antibacterial activity increased as the length of the C-13 aliphatic side chain increased. The effects of the oxygen-substituents on aromatic rings A, C, and D of protoberberinium salts 13-20 on the antimicrobial activity against Staphylococcus aureus, B. subtilis, S. enteritidis, Escherichia coli, and Candida… CONTINUE READING
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