Structure-activity relationships of poly(L-lysines): effects of pegylation and molecular shape on physicochemical and biological properties in gene delivery.

Abstract

The influence of shape, molecular weight and pegylation of linear, grafted, dendritic and branched poly-L-lysines on their DNA delivery properties were investigated. DNA binding, condensation, complex size and morphology, cell uptake and transfection efficiency were determined. Most polylysines condense DNA, linear polymers being more efficient than most… (More)

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@article{Mnnist2002StructureactivityRO, title={Structure-activity relationships of poly(L-lysines): effects of pegylation and molecular shape on physicochemical and biological properties in gene delivery.}, author={Marjo M{\"a}nnist{\"o} and Sylvie Vanderkerken and Veska Toncheva and Matti A Elomaa and Marika Ruponen and Etienne H Schacht and Arto Urtti}, journal={Journal of controlled release : official journal of the Controlled Release Society}, year={2002}, volume={83 1}, pages={169-82} }