Structure-activity relationships of peptide T-related pentapeptides.

  title={Structure-activity relationships of peptide T-related pentapeptides.},
  author={Mauro Marastoni and Severo Salvadori and Gianfranco Balboni and Susanna Spisani and Riccardo Gavioli and Serena Traniello and Roberto Tomatis},
  volume={39 8},
Fifteen pentapeptide analogs of C-terminal fragment of peptide T, H-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-OH, were prepared and tested for human monocyte chemotaxis. Structure-activity studies suggest that the potent chemotactic activity of H-Thr-Thr-Asn-Tyr-Thr-OH is mediated through the polar properties of the C-terminal carboxyl group and Thr side chains at… CONTINUE READING