Structure-activity relationships of parathyroid hormone analogs in the opossum kidney cell line.

@article{Cole1989StructureactivityRO,
  title={Structure-activity relationships of parathyroid hormone analogs in the opossum kidney cell line.},
  author={Judith A. Cole and David Carnes and Leonard Ralph Forte and Sammy L. Eber and R E Poelling and Phil Thorne},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1989},
  volume={4 5},
  pages={723-30}
}
Structural alterations in the parathyroid hormone (PTH) molecule produce marked changes in biologic activity. We examined the relative sensitivity of PTH-stimulated cAMP formation and PTH-inhibitable Na+-dependent phosphate transport responses to bovine PTH analogs [bPTH-(1-34), bPTH-(1-84), 8,18-norleucine-34-tyrosinamide bPTH-(1-34), bPTH-(7-34)-amide, 8,18-norleucine-34-tyrosinamide bPTH-(3-34), transaminated bPTH-(1-34)] and the human PTH-related peptide of malignancy (1-34) in cultured… CONTINUE READING