Structure-activity relationships of estrogens.

  title={Structure-activity relationships of estrogens.},
  author={V. Craig Jordan and Suneeta Mittal and B. Gosden and Rainhard Koch and Mark E. Lieberman},
  journal={Environmental Health Perspectives},
  pages={97 - 110}
The last 50 years has seen an exponential rise in the published reports about estrogen action. The model to describe the early events in the mechanism of action of estrogens via the estrogen receptor is updated in this paper to incorporate some of the recent data on the subcellular localization of the receptor. New evidence suggests that the receptor is a nuclear protein, so it appears that estrogens must first diffuse into the nuclear compartment to initiate estrogen action via the receptor… CONTINUE READING
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