Structure-activity relationships of omega-conotoxins at N-type voltage-sensitive calcium channels.

@article{Nielsen2000StructureactivityRO,
  title={Structure-activity relationships of omega-conotoxins at N-type voltage-sensitive calcium channels.},
  author={Katherine J. Nielsen and Thomas Schr{\"o}der and Richard Lewis},
  journal={Journal of molecular recognition : JMR},
  year={2000},
  volume={13 2},
  pages={55-70}
}
Due to their selectivity towards voltage-sensitive calcium channels (VSCCs) omega-conotoxins are being exploited as a new class of therapeutics in pain management and may also have potential application in ischaemic brain injury. Here, the structure-activity relationships (SARs) of several omega-conotoxins including GVIA, MVIIA, CVID and MVIIC are explored. In addition, the three-dimensional structures of these omega-conotoxins and some structurally related peptides that form the cysteine knot… CONTINUE READING

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