Structure-activity relationships of arginine analogues on nitric oxide synthase activity in the rat brain

@article{Yokoi1994StructureactivityRO,
  title={Structure-activity relationships of arginine analogues on nitric oxide synthase activity in the rat brain},
  author={Isao Yokoi and Hideaki Kabuto and Hiroto Habu and Kazunori Inada and Jonathan Toma and Akihisa Mori},
  journal={Neuropharmacology},
  year={1994},
  volume={33},
  pages={1261-1265}
}
Nitric oxide (NO) is synthesized by nitric oxide synthase (NOS) from L-arginine (Arg) which has a guanidino group in its molecule. We examined the effect of 23 different Arg analogues on NOS activity in the rat brain. Though homoarginine, epsilon-guanidinocaproic acid and canavanine act as substrates of NOS, production of NO from them was lower than that from Arg. alpha-Guanidinoglutaric acid (2-GGA) and arcaine inhibited NOS activity at levels equal to NG-monomethyl-L-arginine (MeArg), a well… CONTINUE READING