Structure-activity relationships of HIV-1 PR inhibitors containing AHPBA--II. Modification of pyrrolidine ring at P1' proline.

Abstract

Systematic replacement in the 3- or 4-position of the pyrrolidine ring at P1' proline was carried out. Compound 26, which has a Cl atom in the 4(S)-position was the most active among inhibitors substituted with other halogen atoms or other substituents. Furthermore, the replacement of the Z group in compound 26 with five- or six-membered fused aromatic… (More)

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@article{Komai1996StructureactivityRO, title={Structure-activity relationships of HIV-1 PR inhibitors containing AHPBA--II. Modification of pyrrolidine ring at P1' proline.}, author={Tomoaki Komai and Shusaku Higashida and Masatoshi Sakurai and Takenori Nitta and Atsushi Kasuya and S Miyamaoto and Rika Yagi and Yuri Ozawa and Hiroshi Handa and Hiromi Mohri and Asako Yasuoka and Shinichi Oka and Takashi Nishigaki and S-i Kimura and Kazuyuki Shimada and Yoko Yabe}, journal={Bioorganic & medicinal chemistry}, year={1996}, volume={4 8}, pages={1365-77} }