Structure-activity relationships of β-hairpin mimics as modulators of amyloid β-peptide aggregation.

@article{Tonali2018StructureactivityRO,
  title={Structure-activity relationships of β-hairpin mimics as modulators of amyloid β-peptide aggregation.},
  author={Nicolo Tonali and Julia Kaffy and Jean-Louis Soulier and Maria Luisa Gelmi and Emanuela Erba and Myriam Taverna and Carine van Heijenoort and T{\^a}p Ha-Duong and Sandrine Ongeri},
  journal={European journal of medicinal chemistry},
  year={2018},
  volume={154},
  pages={
          280-293
        }
}
Aggregation of amyloid proteins is currently involved in more than 20 serious human diseases that are actually untreated, such as Alzheimer's disease (AD). Despite many efforts made to target the amyloid cascade in AD, finding an aggregation inhibiting compound and especially modulating early oligomerization remains a relevant and challenging strategy. We report herein the first examples of small and non-peptide mimics of acyclic beta-hairpins, showing an ability to delay the fibrillization of… CONTINUE READING
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