Structure-activity relationships in halogenated biphenyls: unifying hypothesis for structural specificity.

@article{McKinney1981StructureactivityRI,
  title={Structure-activity relationships in halogenated biphenyls: unifying hypothesis for structural specificity.},
  author={James D. McKinney and Pushpanjali Singh},
  journal={Chemico-biological interactions},
  year={1981},
  volume={33 2-3},
  pages={
          271-83
        }
}
Using chlorinated biphenyls as model halogenated aromatic hydrocarbons, in this and previous work we have investigated the specific structural requirements for induction of cytochrome P-448, P-450 and associated monooxygenase activities, and exquisite toxicity in the guinea pig. The requirement of planarity of coplanarity was examined using single crystal X-ray techniques to describe the structure and conformation of PCBs and PBs in the solid state as an approximation of their interactions with… CONTINUE READING
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