Structure-activity relationships in halogenated biphenyls: unifying hypothesis for structural specificity.

@article{McKinney1981StructureactivityRI,
  title={Structure-activity relationships in halogenated biphenyls: unifying hypothesis for structural specificity.},
  author={James D. McKinney and Pushpanjali Singh},
  journal={Chemico-biological interactions},
  year={1981},
  volume={33 2-3},
  pages={271-83}
}
Using chlorinated biphenyls as model halogenated aromatic hydrocarbons, in this and previous work we have investigated the specific structural requirements for induction of cytochrome P-448, P-450 and associated monooxygenase activities, and exquisite toxicity in the guinea pig. The requirement of planarity of coplanarity was examined using single crystal X… CONTINUE READING