Structure-activity relationships for vitamin D3-based aromatic a-ring analogues as hedgehog pathway inhibitors.

@article{Deberardinis2014StructureactivityRF,
  title={Structure-activity relationships for vitamin D3-based aromatic a-ring analogues as hedgehog pathway inhibitors.},
  author={Albert M Deberardinis and Daniel J. Madden and Upasana Banerjee and Vibhavari Sail and Daniel S. Raccuia and Daniel De Carlo and Steven M. Lemieux and Adam Meares and M Kyle Hadden},
  journal={Journal of medicinal chemistry},
  year={2014},
  volume={57 9},
  pages={
          3724-36
        }
}
A structure-activity relationship study for a series of vitamin D3-based (VD3) analogues that incorporate aromatic A-ring mimics with varying functionality has provided key insight into scaffold features that result in potent, selective Hedgehog (Hh) pathway inhibition. Three analogue subclasses containing (1) a single substitution at the ortho or para position of the aromatic A-ring, (2) a heteroaryl or biaryl moiety, or (3) multiple substituents on the aromatic A-ring were prepared and… CONTINUE READING
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