Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.

@article{Ekinci2012StructureactivityRF,
  title={Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.},
  author={Deniz Ekinci and H{\"u}seyin Çavdar and Serdar Durdagi and Oktay Talaz and Murat Şent{\"u}rk and Claudiu T. Supuran},
  journal={European journal of medicinal chemistry},
  year={2012},
  volume={49},
  pages={68-73}
}
Several 5,10-dihydroindeno[1,2-b]indole derivatives incorporating methoxy, hydroxyl, and halogen (F, Cl, and Br) moieties on the indene fragment of the molecule were prepared and tested against five carbonic anhydrase (CA, EC 4.2.1.1) isoforms. The inhibitory potencies of these compounds against the human (h) isoforms hCA I, II, IV, VI and bovine (b) isoform bCA III were assessed. Most of them exhibited low micromolar inhibition of these enzymes. K(I) values of these compounds against hCA I and… CONTINUE READING

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