Structure-activity relationships for insecticidal carbamates.

  title={Structure-activity relationships for insecticidal carbamates.},
  author={Robert L. Metcalf},
  journal={Bulletin of the World Health Organization},
  volume={44 1-3},
Carbamate insecticides are biologically active because of their structural complementarity to the active site of acetylcholinesterase (AChE) and their consequent action as substrates with very low turnover numbers. Carbamates behave as synthetic neurohormones that produce their toxic action by interrupting the normal action of AChE so that acetylcholine accumulates at synaptic junctions. The necessary properties for a suitable insecticidal carbamate are lipid solubility, suitable structural… CONTINUE READING