Structure-activity relationships among a group of 7-(alpha-(N,N'-substituted-amidinothio)-acetamido) cephalosphoranic acids.


Structure-activity relationships were examined for a number of 7-[alpha-(N,N'-substituted-amidinothio)-acetamido] cephalosporanic acids, including several wherein the amidino group was cyclized into six, seven, and eight-membered rings and a series wherein alkyl, cycloalkyl, alkenyl, and alkynyl radicals were substituted on the nitrogens of the noncyclized… (More)


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