Structure-activity relationships among N-arachidonylethanolamine (Anandamide) head group analogues for the anandamide transporter.

@article{Jarrahian2000StructureactivityRA,
  title={Structure-activity relationships among N-arachidonylethanolamine (Anandamide) head group analogues for the anandamide transporter.},
  author={Abbas Jarrahian and S. Manna and William S Edgemond and William Campbell and Cecilia J. Hillard},
  journal={Journal of neurochemistry},
  year={2000},
  volume={74 6},
  pages={2597-606}
}
Two putative endocannabinoids, N-arachidonylethanolamine (AEA) and 2-arachidonylglycerol, are inactivated by removal from the extracellular environment by a process that has the features of protein-mediated facilitated diffusion. We have synthesized and studied 22 N-linked analogues of arachidonylamide for the purpose of increasing our understanding of the structural requirements for the binding of ligands to the AEA transporter. We have also determined the affinities of these analogues for… CONTINUE READING
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