Structure-activity relationship study of the bacterial actin-like protein MreB inhibitors: effects of substitution of benzyl group in S-benzylisothiourea.

Abstract

We comprehensively investigated the effects of substitution of the benzyl group in S-benzylisothiourea derivatives on antibacterial activity, because we found previously that some substitutions enhanced it. A 2,4-Cl2-derivative was found to be the most effective compound, it was stronger than the original one in Gram-negative rod shaped-bacteria such as Escherichia coli and Salmonella typhimurium.

Cite this paper

@article{Iwai2007StructureactivityRS, title={Structure-activity relationship study of the bacterial actin-like protein MreB inhibitors: effects of substitution of benzyl group in S-benzylisothiourea.}, author={Noritaka Iwai and Takuya Fujii and Hirokatsu Nagura and Masaaki Wachi and Tomoya Kitazume}, journal={Bioscience, biotechnology, and biochemistry}, year={2007}, volume={71 1}, pages={246-8} }