Structure-activity relationship study of biflavonoids on the Dengue virus polymerase DENV-NS5 RdRp.

@article{Coulerie2013StructureactivityRS,
  title={Structure-activity relationship study of biflavonoids on the Dengue virus polymerase DENV-NS5 RdRp.},
  author={Paul Coulerie and Mohammed Nour and Alexandre Maciuk and C{\'e}cilia Eydoux and Jean Claude Guillemot and Nicolas Lebouvier and Edouard Hnawia and Karine Leblanc and Guy Lewin and Bruno Canard and Bruno Figad{\`e}re},
  journal={Planta medica},
  year={2013},
  volume={79 14},
  pages={
          1313-8
        }
}
Dengue virus is the world's most prevalent human pathogenic arbovirus. There is currently no treatment or vaccine, and solutions are urgently needed. We previously demonstrated that biflavonoids from Dacrydium balansae, an endemic gymnosperm from New Caledonia, are potent inhibitors of the Dengue virus NS5 RNA-dependent RNA polymerase. Herein we describe the structure-activity relationship study of 23 compounds: biflavonoids from D. balansae (1-4) and from D. araucarioides (5-10), hexamethyl… Expand
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