Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells.

Abstract

Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S3 cells was investigated. Compared to glaziovianin A, the O7-allyl derivative was found to be more cytotoxic against HeLa S3 cells and a more potent M-phase inhibitor.

DOI: 10.1016/j.bmcl.2010.07.111

Cite this paper

@article{Ikedo2010StructureactivityRS, title={Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells.}, author={Akiyuki Ikedo and Ichiro Hayakawa and Takeo Usui and Sayaka Kazami and Hiroyuki Osada and Hideo Kigoshi}, journal={Bioorganic & medicinal chemistry letters}, year={2010}, volume={20 18}, pages={5402-4} }