Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels.

@article{Yamamoto2006StructureactivityRS,
  title={Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels.},
  author={Takashi Yamamoto and Seiji Niwa and Seiji Ohno and Tomoyuki Onishi and Hiroyuki Matsueda and Hajime Koganei and Hisayuki Uneyama and Shin-ichi Fujita and Tomoko Takeda and Morikazu Kito and Yukitsugu Ono and Yuki Saitou and Akira Takahara and Seinosuke Iwata and Masataka Shoji},
  journal={Bioorganic & medicinal chemistry letters},
  year={2006},
  volume={16 4},
  pages={
          798-802
        }
}
Cilnidipine is a 1,4-dihydropyridine derived L/N-type calcium channel dual blocker possessing neuroprotective and analgesic effects which are related to its N-type calcium channel inhibitory activity. In order to find specific N-type calcium channel blockers with the least effects on cardiovascular system, we performed structure-activity relationship study on APJ2708, which is a derivative of cilnidipine, and found a promising N-type calcium channel blocker 21b possessing analgesic effect in… CONTINUE READING

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