Structure-activity relationship study of anoplin.

  title={Structure-activity relationship study of anoplin.},
  author={Dan Ifrah and Xavier Doisy and Trine Skovlund Ryge and Paul Robert Hansen},
  journal={Journal of peptide science : an official publication of the European Peptide Society},
  volume={11 2},
Anoplin is a decapeptide amide, GLLKRIKTLL-NH2 derived from the venom sac of the solitary spider wasp, Anoplius samariensis. It is active against Gram-positive and Gram-negative bacteria and is not hemolytic towards human erythrocytes. The present paper reports a structure-activity study of anoplin based on 37 analogues including an Ala-scan, C- and N-truncations, and single and multiple residue substitutions with various amino acids. The analogues were tested for antibacterial activity against… CONTINUE READING

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