Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7.


Necroptosis is a regulated caspase-independent cell death mechanism characterized by morphological features resembling non-regulated necrosis. Necrotatin-7 (Nec-7), a novel potent small-molecule inhibitor of necroptosis, is structurally distinct from previously described necrostatins (Nec-1, Nec-3, Nec-4 and Nec-5). Here, we describe a series of structural… (More)
DOI: 10.1016/j.bmcl.2008.08.058


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