Structure-activity relationship studies on clinically relevant HIV-1 NNRTIs.

  title={Structure-activity relationship studies on clinically relevant HIV-1 NNRTIs.},
  author={Ravindra K. Rawal and Vanangamudi Murugesan and Seturam B Katti},
  journal={Current medicinal chemistry},
  volume={19 31},
In addition to the nucleoside reverse transcriptase inhibitors (NRTIs), protease inhibitors (PIs) and integrase inhibitors (INIs), nonnucleoside reverse transcriptase inhibitors (NNRTIs) have contributed significantly in the treatment of HIV-1 infections. More than 60 structurally different classes of compounds have been identified as NNRTIs, which are specifically inhibiting HIV-1 reverse transcriptase (RT). Five NNRTIs (nevirapine, delavirdine, efavirenz, etravirine and rilpivirine) have been… CONTINUE READING