Structure-activity relationship studies of novel oxygen-incorporated SAHA analogues.

@article{Kim2009StructureactivityRS,
  title={Structure-activity relationship studies of novel oxygen-incorporated SAHA analogues.},
  author={Soon-Ai Kim and Ying Lan Jin and Hak Sung Kim},
  journal={Archives of pharmacal research},
  year={2009},
  volume={32 1},
  pages={15-21}
}
Novel oxygen-incorporated SAHA (oxa-SAHA) analogues, in which oxygen was inserted in the alkyl linker connecting the hydroxamic acid moiety and amide group, were synthesized and their inhibitory activities on histone deacetylase were evaluated. The most active oxa-SAHA analogue potently inhibited histone deacetylase, almost as potently as SAHA. Various… CONTINUE READING