Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative.

@article{Long2005StructureactivityRS,
  title={Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative.},
  author={Kai Long and Michael Boyce and He Lin and Junying Yuan and Dawei Ma},
  journal={Bioorganic & medicinal chemistry letters},
  year={2005},
  volume={15 17},
  pages={3849-52}
}
The synthesis and structure-activity relationships (SAR) of salubrinal, a small molecule that protects cells from apoptosis induced by endoplasmic reticulum (ER) stress, are described. It is revealed that the trichloromethyl group greatly contributes to the activity. Based on the SAR results, salubrinal was converted into a biotinylated derivative which retains activity and can be used as a biological tool for target identification. 

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