Structure-activity relationship studies of curcumin analogues.

  title={Structure-activity relationship studies of curcumin analogues.},
  author={James R Fuchs and Bulbul Pandit and Deepak Bhasin and Jonathan P. Etter and Nicholas Regan and Dalia S Abdelhamid and Chenglong Li and Jiayuh Lin and Pui-kai Li},
  journal={Bioorganic & medicinal chemistry letters},
  volume={19 7},
Two series of curcumin analogues, a total of twenty-four compounds, were synthesized and evaluated. The most potent compound, compound 23, showed potent growth inhibitory activities on both prostate and breast cancer lines with IC(50) values in sub-micromolar range, fifty times more potent than curcumin. Curcumin analogues might be potential anti-tumor agents for breast and prostate cancers.