Structure-activity relationship studies of a series of novel delta-lactam-based histone deacetylase inhibitors.

Abstract

We synthesized a series of delta-lactam-based HDAC inhibitors that were identified with various degrees of anti-inflammatory and cell growth inhibitory activities. Compounds possessing significant HDAC inhibitory activity exhibited both anti-inflammatory and cell growth inhibitory activities as well as significant tumor growth inhibition in the in vivo… (More)

5 Figures and Tables

Topics

  • Presentations referencing similar topics