Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists.

@article{Zheng2005StructureactivityRO,
  title={Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists.},
  author={Guo Zhu Zheng and Pramila Bhatia and Jerome F Daanen and Teodozyj Kolasa and Meena V Patel and Steven P Latshaw and Odile F El Kouhen and Renjie Chang and Marie E. Uchic and Loan N Miller and Masaki Nakane and Sonya G. Lehto and Marie P Honore and Robert B. Moreland and Jorge D. Brioni and Andrew O. Stewart},
  journal={Journal of medicinal chemistry},
  year={2005},
  volume={48 23},
  pages={7374-88}
}
SAR (structure-activity relationship) studies of triazafluorenone derivatives as potent mGluR1 antagonists are described. The triazafluorenone derivatives are non-amino acid derivatives and noncompetitive mGluR1 antagonists that bind at a putative allosteric recognition site located within the seven-transmembrane domain of the receptor. These triazafluorenone derivatives are potent, selective, and systemically active mGluR1 antagonists. Compound 1n, for example, was a very potent mGluR1… CONTINUE READING

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…