Structure-activity relationship of retinoids on lobuloalveolar differentiation of cultured mouse mammary glands.

  title={Structure-activity relationship of retinoids on lobuloalveolar differentiation of cultured mouse mammary glands.},
  author={Andreas Kistler},
  volume={7 7},
  • A. Kistler
  • Published 1 July 1986
  • Biology, Medicine
  • Carcinogenesis
The influence of 28 retinoids on the structural differentiation of mouse mammary glands in whole organ cultures was examined. Mammary glands from BALB/c mice pretreated with steroids (estradiol and progesterone) and cultured in the presence of lactogenic hormones (insulin, prolactin, hydrocortisone and aldosterone) differentiate into lobuloalveolar structures. These differentiation processes were inhibited by retinoic acid at 10(-6) M and by the arotinoid containing tetramethylated tetraline… 

Modulation of normal mammary epithelial cell proliferation, morphogenesis, and functional differentiation by retinoids: a comparison of the retinobenzoic acid derivative RE80 with retinoic acid.

Several mechanisms may contribute to the chemopreventive and/or therapeutic efficacy of retinoids in breast cancer, including inhibition of proliferation, stimulation of cell death, and/ or induction of differentiation.

Retinoic acid signaling is required for proper morphogenesis of mammary gland

It is demonstrated that RA is required for proper morphogenesis of mouse mammary gland in a novel transgenic mouse model system and evidence suggesting that retinoic acid signaling is required to maintain the homeostasis of mammary glands morphogenesis is provided.

Limb bud cell cultures for estimating the teratogenic potential of compounds

  • A. Kistler
  • Biology, Medicine
    Archives of Toxicology
  • 2004
The results suggest that the limb bud cell culture system may be useful for a preliminary testing to select non-teratogenic retinoids for the risk assessment in humans, however, the in vitro result should be verified in animal studies.

Teratogenicity of arotinoids (retinoids) in vivo and in vitro

There was a good quantitative correlation between the in vivo teratogenicity and the in vitro activity in limb bud cells but no correlation was found in midbrain cells, so the limb bud cell culture system may be useful for a preliminary testing to select non-teratogenic retinoids.

Changes associated with delay of mammary cancer by retinoid analogues in transgenic mice bearing c-neu oncogene

The TG.NK transgenic mouse line on FVB strain background expresses the c-neu oncogene under the control of a MMTV promoter in mammary tissue and appears to be a useful animal model for evaluation of strategies to delay or prevent mammary cancer.

The Role of Fatty Acids in Murine and Human Mammary Carcinogenesis: An InVitro Approach

Because of distinct strain-dependent differences in tumorigenesis in mice that are usually accompanied by a specific preneoplastic morphologic atypia, the effects of dietary modulators on mammary cell proliferation, differentiation and tumorigenic transformation have been extensively investigated.

Binding Protein-II Mammary Carcinoma Suppression by Cellular Retinoic Acid Updated Version

It is revealed that endogenous levels of RA are sufficient for maximal tumor suppression on CRABP-II overexpression, and plays a critical role in sensitizing tumors to the growth-suppressive activities of RA in vivo.

Adolescent Vitamin A Intake Alters Susceptibility to Mammary Carcinogenesis in the Sprague-Dawley Rat

It is demonstrated that vitamin A intake during adolescence alters mammary gland differentiation and indicate that a narrow range of vitamin A consumption during adolescence protects against carcinogenesis.

Transcription Factor Smad3 Is Required for the Inhibition of Adipogenesis by Retinoic Acid*

Using preadipocytes and mesenchymal stem cell models, it is shown that RA specifically blocks the occupancy of C/EBPβ of the Cebpa promoter, thereby abrogating the differentiation process, and Smad3 is necessary to convey the inhibitory effects of retinoic acid during adipogenesis.

Structure-toxicity relationships of the tetramethylated tetralin and indane analogs of retinoic acid.

The present results are consistent with previous studies showing that the presence of or biotransformation to a free acid congener was necessary for retinoid teratogenic activity in hamsters and that increasing conformational restriction of acidic retinoids increased Teratogenic potency.