Structure-activity relationship of retinoids on lobuloalveolar differentiation of cultured mouse mammary glands.

@article{Kistler1986StructureactivityRO,
  title={Structure-activity relationship of retinoids on lobuloalveolar differentiation of cultured mouse mammary glands.},
  author={Andreas Kistler},
  journal={Carcinogenesis},
  year={1986},
  volume={7 7},
  pages={
          1175-82
        }
}
  • A. Kistler
  • Published 1 July 1986
  • Biology, Medicine
  • Carcinogenesis
The influence of 28 retinoids on the structural differentiation of mouse mammary glands in whole organ cultures was examined. Mammary glands from BALB/c mice pretreated with steroids (estradiol and progesterone) and cultured in the presence of lactogenic hormones (insulin, prolactin, hydrocortisone and aldosterone) differentiate into lobuloalveolar structures. These differentiation processes were inhibited by retinoic acid at 10(-6) M and by the arotinoid containing tetramethylated tetraline… 

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