Structure-activity relationship of piperine and its synthetic analogues for their inhibitory potentials of rat hepatic microsomal constitutive and inducible cytochrome P450 activities.

@article{Koul2000StructureactivityRO,
  title={Structure-activity relationship of piperine and its synthetic analogues for their inhibitory potentials of rat hepatic microsomal constitutive and inducible cytochrome P450 activities.},
  author={Surrinder Koul and Jawahir Lal Koul and Subhash Chandra Taneja and Kanaya Lal Dhar and Deshvir S. Jamwal and Kuldeep Singh and Rashmeet K Reen and Jaswant Singh},
  journal={Bioorganic & medicinal chemistry},
  year={2000},
  volume={8 1},
  pages={251-68}
}
Inhibitors of drug metabolism have important implications in pharmaco-toxicology and agriculture. We have reported earlier that piperine, a major alkaloid of black and long peppers inhibits both constitutive and inducible cytochrome P450 (CYP)-dependent drug metabolising enzymes. In the present study, an attempt has been made to prepare several novel synthetic analogues so as to relate various modifications in the parent molecule to the inhibition of CYP activities. Two types of mono-oxygenase… CONTINUE READING

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