Structure activity relationship of carotenoid derivatives in activation of the electrophile/antioxidant response element transcription system.

@article{Linnewiel2009StructureAR,
  title={Structure activity relationship of carotenoid derivatives in activation of the electrophile/antioxidant response element transcription system.},
  author={Karin Linnewiel and Hansgeorg Ernst and Catherine Caris-Veyrat and Anat Ben-Dor and Arie Kampf and Hagar Salman and Michael Danilenko and Joseph Levy and Yoav Sharoni},
  journal={Free radical biology & medicine},
  year={2009},
  volume={47 5},
  pages={659-67}
}
Induction of phase II detoxifying enzymes is a major cellular strategy for reducing the risk of cancer. We previously reported that carotenoids activate the electrophile/antioxidant response element (EpRE/ARE) transcription system and induced the expression of phase II enzymes. Various electrophilic phytonutrients have been shown to induce the EpRE/ARE system by disrupting the inhibitory activity of Keap1 on Nrf2, the major EpRE/ARE activating transcription factor. However, hydrophobic… CONTINUE READING

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