Structure-activity relationship of bile acids and bile acid analogs in regard to FXR activation.

Abstract

The farnesoid X receptor (FXR) is a bile acid-activated nuclear receptor that plays a major role in bile acid and cholesterol metabolism. To obtain an insight into the structure-activity relationships of FXR ligands, we investigated the functional roles of structural elements in the physiological ligands chenodeoxycholic acid [CDCA; (3alpha,7alpha)], cholic… (More)

Topics

  • Presentations referencing similar topics