Structure activity relationship of antiproliferative N-acyl-beta-alanine amides.

Starting from the antiproliferative N-homofarnesoyl-beta-alanine amide 1 as a lead structure we have demonstrated that the homofarnesoyl residue of 1 can be replaced by several aliphatic and aromatic acyl moieties which offer advantages in terms of availability and stability over the original homofarnesoyl residue. The N-(2,3-dimethylphenyl… (More)