Structure-activity relationship in the gastric cytoprotective effect of several sesquiterpene lactones.

  title={Structure-activity relationship in the gastric cytoprotective effect of several sesquiterpene lactones.},
  author={Oscar S. Giordano and Mauricio J. Pestchanker and Eduardo Guerreiro and Jos{\'e} Roberto Saad and Ricardo D. Enriz and A. M. Rodrı́guez and E. A. J{\'a}uregui and Jorge A. Guzm{\'a}n and Alejandra O Mar{\'i}a and Graciela Hayd{\'e}e Wendel},
  journal={Journal of medicinal chemistry},
  volume={35 13},
The structural requirements for the gastric cytoprotective activity of several sesquiterpene lactones are reported. A theoretical-experimental study on the potentially active centers is carried out. The biological evaluation of reduced analogues and the simulation of the molecular interactions between these compounds and an endogenous cysteine residue suggest that the presence of a non sterically hindered Michael acceptor seems to be an essential structural requirement for the cytoprotective… Expand
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