Structure-activity relationship in synthetic fibrinolytics. 2-Phenethynylcyclopropanecarboxylates.


The fibrinolytic activity of nine 2-phenethynylcyclopropanecarboxylates was measured in the hanging clot test. The structure-activity relationship is given by log 1/C equals 0.54 log P + 2.01 where P is the octanol-water partition coefficient of the carboxylate ion pair and C is the molar concentration of the drug. The equation obtained for the cyclopropanecarboxylates is compared with similar equations for benzoates, salicylates, and N-phenylanthranilates.

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@article{Yoshimoto1975StructureactivityRI, title={Structure-activity relationship in synthetic fibrinolytics. 2-Phenethynylcyclopropanecarboxylates.}, author={Motoko Yoshimoto and K N von Kaulla and Corwin Hansch}, journal={Journal of medicinal chemistry}, year={1975}, volume={18 9}, pages={950-1} }