Structure-activity and cross-resistance evaluations of a series of human immunodeficiency virus type-1-specific compounds related to oxathiin carboxanilide.

@article{Buckheit1995StructureactivityAC,
  title={Structure-activity and cross-resistance evaluations of a series of human immunodeficiency virus type-1-specific compounds related to oxathiin carboxanilide.},
  author={R. Buckheit and T. Kinjerski and V. Fliakas-Boltz and J. Russell and T. L. Stup and L. Pallansch and W. G. Brouwer and D. Dao and W. Harrison and R. J. Schultz},
  journal={Antimicrobial agents and chemotherapy},
  year={1995},
  volume={39},
  pages={2718 - 2727}
}
  • R. Buckheit, T. Kinjerski, +7 authors R. J. Schultz
  • Published 1995
  • Biology, Medicine
  • Antimicrobial agents and chemotherapy
  • A series of compounds related to the nonnucleoside reverse transcriptase (RT) inhibitor (NNRTI) oxathiin carboxanilide (UC84) were evaluated for activity against the human immunodeficiency virus (HIV) to determine structural requirements for anti-HIV activity. Twenty-seven compounds representative of the more than 400 Uniroyal Chemical Company (UC) compounds were evaluated for structure-activity relationships. Several of the compounds evaluated were highly active, with 50% effective… CONTINUE READING
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