Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling.

@article{Fonseca2012StructureactivityAO,
  title={Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling.},
  author={Bruno D Fonseca and Graham H. Diering and Michael A Bidinosti and Kush Dalal and Tommy Alain and Aruna D. Balgi and Roberto Forestieri and Matt Nodwell and Charles V Rajadurai and Cynthia Gunaratnam and Andrew R Tee and Franck Duong and Raymond J Andersen and John Orlowski and Masayuki Numata and Nahum Sonenberg and Michel Roberge},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 21},
  pages={
          17530-45
        }
}
Mammalian target of rapamycin complex 1 (mTORC1) signaling is frequently dysregulated in cancer. Inhibition of mTORC1 is thus regarded as a promising strategy in the treatment of tumors with elevated mTORC1 activity. We have recently identified niclosamide (a Food and Drug Administration-approved antihelminthic drug) as an inhibitor of mTORC1 signaling. In the present study, we explored possible mechanisms by which niclosamide may inhibit mTORC1 signaling. We tested whether niclosamide… CONTINUE READING

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